Dapoxetine

Key points

• Engineered for rapid absorption and a short duration in the body, it is taken as needed rather than daily like standard antidepressant SSRIs.
• Combination products such as Cenforce D and Tadapox pair it with an erectile dysfunction medicine.
• By boosting serotonin signalling in the brain regions that govern ejaculatory response, it lengthens the time before climax is reached.

What is Dapoxetine?

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) adapted for quick absorption and rapid activity. Unlike daily SSRIs used for long-term mood regulation, this compound is engineered to remain active in the system just long enough to improve ejaculatory control. Because this medication only addresses immediate physiological responses, it is used on an as-needed basis.

What Dapoxetine is used for

This medication is primarily used to address Premature Ejaculation. Many available formulations combine it with another active ingredient to concurrently manage Erectile Dysfunction. By targeting both ejaculatory control and erectile response, these combination tablets or gels provide a multifaceted approach for individuals experiencing these specific challenges.

How does Dapoxetine work?

Dapoxetine functions by increasing the level of serotonin in the nervous system. Serotonin is a neurotransmitter that sends signals between nerve cells. By increasing its activity in the areas of the brain responsible for ejaculatory response, the time taken to reach climax is typically extended. This mechanism allows for greater control over the duration of sexual activity.

Dapoxetine brands and forms

Dapoxetine on its own is Priligy and the generic Poxet. The combinations pair it with sildenafil (Cenforce D), tadalafil (Tadapox), vardenafil (Levitra with Dapoxetine) or avanafil (Super Avana). Elsewhere the sildenafil combination is also sold as Super Kamagra and Super P-Force. For broader options and treatment insights, see our Premature Ejaculation and Erectile Dysfunction sections.

Safety overview for Dapoxetine

What to check before using this medicine

Ensure you do not have known allergies to SSRI medications or pre-existing heart conditions. Those with a history of fainting, mood disorders, or liver issues should exercise caution before use.

Possible reactions and tolerability

While generally well-tolerated, some individuals may experience nausea, dizziness, or mild headaches shortly after use. These effects typically subside as the medication wears off.

Interactions and health factors

Avoid mixing this medication with alcohol, as it may worsen potential side effects like dizziness. It is not suitable for use alongside certain antidepressants, MAO inhibitors, or other drugs impacting serotonin levels, as this can lead to severe interactions. Product labelling and verified clinical sources remain the correct references for specific contraindications, interactions and reactions.

What the sources say

• Dapoxetine may cause fainting or dizziness. You may feel sleepy, dizzy, faint, have difficulty concentrating or experience blurred vision while taking it. (EMA)
• Dapoxetine should not be taken by anyone with moderate or severe liver problems. (EMA)

Further reading

• Premature ejaculation | The British Association of Urological … - BAUS
• Priligy Article 29 referral, Annex III: Summary of Product Characteristics, Labelling and Package Leaflet
• Priligy - healthdirect
• Priligy - NPS MedicineWise